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Helicobacter pylori

German: Helicobacter pylori

1 Definition

Helicobacter pylori are spirally bent, gram-negative rod-shaped bacteria with lophotrichous flagella.

2 Pathogenesis

Helicobacter pylori is almost exclusively found in humans. After fecal oral transmission the colonization and infection of the gastric mucous membrane takes place.

Helicobacter species can also be found in various animals (i.e. dogs and cats). Amongst others: Helicobacter felis, Helicobacter bizzozeronii and Helicobacter bilis. For them it has not been proven yet if a colonization of the stomach leads to diseases. .[1]

Pathogenicity factors:

3 Clinical pictures

Most people ( 85%) with Helicobacter pylori infections present asymptomatic.

Currently, the protective effect of a Helicobacter pylori infection with regards to the development of a gastroesophageal reflux disease or Barrett’s esophagus are being discussed.

4 Diagnosis

5 Treatment

Helicobacter pylori infections are treated with a triple therapy (e.g. Omeprazol, Metronidazol, Clarithromycin) for a minimum of 7 days. [2] This therapy is referred to as Helicobacter pylori eradication.

6 Sources

  1. Mulchandani et al. Detection of Helicobacter Species from Dog Stomachs. Research and Reviews: Journal of Veterinary Science and Technology; 2013
  2. Fischbach et al. Helicobacter pylori und gastroduodenale Ulkuskrankheit. Dtsch Arztebl Int; 2009

7 Literature

Kusters et al. Pathogenesis of Helicobacter pylori Infection. Clin Microbiol Rev; 2006

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