SUSPUP
1. Definition
SUSPUP (serum sodium to urinary sodium to serum potassium to urinary potassium) und SUSPPUP (serum sodium to urinary sodium to (serum potassium)2 to urinary potassium) sind statische Funktionstests zur Evaluation der mineralokortikoiden Stimulation der Nieren.
2. Berechnung
SUSPUP = [Natrium]Serum / [Natrium]Urin / ([Kalium]Serum / [Kalium]Urin)
SUSPPUP = [Natrium]Serum / [Natrium]Urin / (([Kalium]Serum)2 / [Kalium]Urin)
3. Referenzbereich
| Parameter | 95%-Toleranzintervall | Maßeinheit |
|---|---|---|
| SUSPUP | 3,6 - 22,6 | (entfällt) |
| SUSPPUP | 0,6 - 5,3 | (entfällt) |
4. Klinische Bedeutung
Beide Quotienten eignen sich als Screening-Parameter für die funktionelle Evaluation des Renin-Angiotensin-II-Aldosteron-Systems. Als Bestätigungstest kommt der Aldosteron-Renin-Quotient zum Einsatz.
5. Literatur
- Willenberg HS, Kolentini C, Quinkler M, Cupisti K, Krausch M, Schott M, Scherbaum WA. The serum sodium to urinary sodium to (serum potassium)² to urinary potassium (SUSPPUP) ratio in patients with primary aldosteronism. Eur J Clin Invest. 2009 Jan;39(1):43-50. doi: 10.1111/j. 365-2362.2008.02060.x. Epub 2008 Dec 1. PMID 19067735.
- Yin GS, Zhang SL, Yan L, Li F, Qi YQ, Chen ZC, Cheng H. [New index of using serum sodium and potassium and urine sodium and potassium jointly in screening primary aldosteronism in hypertensive patients]. Zhonghua Yi Xue Za Zhi. 2010 Apr 13;90(14):962-6. PMID 20646645.
- Balaş M, Zosin I, Maser-Gluth C, Hermsen D, Cupisti K, Schott M, Schinner S, Knoefel WT, Scherbaum WA, Willenberg HS. Indicators of mineralocorticoid excess in the evaluation of primary aldosteronism. Hypertens Res. 2010 Aug;33(8):850-6. doi: 10.1038/hr.2010.76. Epub 2010 Jun 3. PMID 20520614.
- Steichen O, Blanchard A, Plouin PF. Assessment of serum sodium to urinary sodium divided by (serum potassium)² to urinary potassium as a screening tool for primary aldosteronism. Eur J Clin Invest. 2011 Feb;41(2):189-94. doi: 10.1111/j.1365-2362.2010.02401.x. Epub 2010 Oct 18. PMID 20955208.