Corpus: Aggrecan
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Synonym: Aggrekan
English: , cartilage-specific proteoglycan core protein (CSPCP), chondroitin sulphate proteoglycan 1
Definition[Bearbeiten]
Aggrecan is a protein found in hyaline cartilage and is categorised as a proteoglycan.
Chemistry[Bearbeiten]
The aggrecan contained in the cartilage is present as an aggregate with hyaluronic acid. The hyaluronic acid forms the backbone of the entire complex, to which up to 100 aggrecan molecules attach themselves via so-called connecting proteins (not covalently!). The complex can reach a size of over 3,000 kDa and the total volume of a bacterium. It contains up to 130 chondroitin sulphate and keratan sulphate side chains.
Function[Bearbeiten]
Because the aggrecan binds large amounts of water and forms organised structures, it gives the cartilage its shock-absorbing effect (together with hyaluronic acid).
Literature[Bearbeiten]
- Duale Reihe Biocheme" - Joachim Rassow et. al., Thieme-Verlag, 3rd edition