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Pickardt Syndrome

Revision as of 20:50, 1 May 2018 by PD Dr. med. Johannes W. Dietrich (Talk | contribs)

Synonyms: Pickardt-Fahlbusch Syndrome, Pickardt's Syndrome
German: Pickardt-Syndrom

1 Definition

The term Pickardt Syndrome refers to a rare form of tertiary Hypothyroidism that is caused by interruption of portal vessels connecting hypothalamus and pituitary.

2 Etiology

Occlusion of portal vessels may origin from tumors or thrombosis. The most common cause is pituitary adenomas with suprasellar extension. Blood flow may also be interrupted by inflammatory diseases.

A congenital form of Pickardt-Fahlbusch syndrome is referred to as Pituitary stalk interruption syndrome (PSIS).

3 Pathophysiology

In the consequence of interrupted blood flow, an inadequately low amount of TRH reaches the anterior pituitary lobe and hence release of TSH is very low, leading to understimulation of the thyroid with hypothyroidism, in spite of functional thyrotropic feedback control.

Other endocrine dysfunctions associated with Pickardt's Syndrome are suprasellar malfunctions like secondary hypogonadism or hyperprolactinemia.

4 Reference

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