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Induced fit model

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1 Definition

The induced fit model also called Koshland's theory is one of two models which describe the enzyme-substrate interaction. The Koshland's theory assumes that the active site of the enzyme changes its spatial form to allow the substrate to interact with the active site of an enzyme.

2 Characteristics

A substrate is bond to the active site of the Enzyme by weak non-covalent bonds:

  • hydrogen bonds
  • hydrophobic interaction
  • ionic interactions
  • Van-der-Waals force


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