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'''CRPS''' stands for '''C'''omplex '''R'''egional '''P'''ain '''S'''yndrome  
 
'''CRPS''' stands for '''C'''omplex '''R'''egional '''P'''ain '''S'''yndrome  
  
 +
''Synonyms: reflex sympathetic dystrophy syndrome, Sudeck's syndrome, causalgia, shoulder-hand syndrome, a.o.''
  
''Synonyms: Reflex sympathetic dystrophy syndrome, Sudeck’s syndrome, causalgia, shoulder-hand syndrome, a.o.''
+
'''''German''': [[:de:CRPS|CRPS]], Morbus Sudeck, Sudeck Krankheit, Sudeck'sche Dystrophie, Sudeck-Dystrophie, Algodystrophie, Sympathalgie, Komplexes regionales Schmerzsyndrom, Sympathische Reflexdystrophie (SRD), Reflex Sympathetic Dystrophy Syndrome (RSD)''
 
+
'''''German:''' CRPS, Morbus Sudeck, Sudeck Krankheit, Sudeck'sche Dystrophie, Sudeck-Dystrophie, Algodystrophie, Sympathalgie, Komplexes regionales Schmerzsyndrom, Sympathische Reflexdystrophie (SRD), Reflex Sympathetic Dystrophy Syndrome (RSD)''
+
 
   
 
   
 
==Definition==
 
==Definition==
The ''CRPS'' is a chronic neurologic disease, which occurs after an injury to the soft tissues or nerves, often in association with the [[fracture]] of an [[extremity]]. The old term “Sudeck’s syndromeâ€? is still frequently used to describe CRPS of type 1 – named after its discoverer Paul Sudeck (1866-1945), a Hamburg-based surgeon.  
+
The '''CRPS''' is a chronic neurologic disease, which occurs after soft tissue or nerve injury, often in association with the [[fracture]] of an [[extremity]]. The old term "Sudeck's syndrome" is still frequently used to describe CRPS of type 1 named after its discoverer Paul Sudeck (1866-1945), a Hamburg-based surgeon.
  
 
==Pathogenesis==
 
==Pathogenesis==
The pathogenesis of CRPS is not completely understood. It has to do with an irregular healing process of the injured tissue. The occurrence of CRPS is not dependent on the severity of the injury; the injury can even be so insignificant that the patient doesn’t remember it. As a result of the injury, a misregulation of the sympathetic nervous system occurs, which hinders the normal healing process and instead stimulates a circulus vitiosus of pain and subsequent reaction of the [[sympathetic nervous system]].
+
The pathogenesis of CRPS is not completely understood, but appears to be associated with a diruption of the healing process of injured tissue. The occurrence of CRPS is not dependent on the severity of the injury; the injury can even be so insignificant that the patient doesn't remember it. As a result of the injury, a misregulation of the [[sympathetic nervous system]] occurs, which hinders the normal healing process and instead stimulates a [[circulus vitiosus]] of pain and subsequent reaction of the sympathetic nervous system.
 +
 
 
==Epidemiology==
 
==Epidemiology==
CRPS occurs in about 1-2% of patients who have had fractures and in approximately 2-5% of patients after peripheral nerve injuries. SymptomsThe CRPS symptoms are unspecific at the beginning and are often falsely interpreted and/or not seriously considered by the treating physician. CRPS is however a disease and not an indisposition. Typical symptoms of the disease are: ·
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CRPS occurs in about 1-2% of patients who have had fractures and in approximately 2-5% of patients after peripheral nerve injuries.  
 +
 
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<dcMediaViewer title = "CRPS Syndrom/Morbus Sudek" showtitle= "yes" align="left" size="m" items="img_5471" />
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 +
==Symptoms==
 +
The CRPS symptoms are unspecific at the beginning and are often falsely interpreted and/or not seriously considered by the treating physician. CRPS is however a [[disease]] and not an [[indispositio]]n. Typical symptoms of the disease are:
  
 
*Burning pain
 
*Burning pain
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*Altered hair and nail growth  
 
*Altered hair and nail growth  
  
Advanced symptoms are: ·
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Advanced symptoms are:
 
*[[Osteoporosis]]
 
*[[Osteoporosis]]
 
*[[Ankylosis]]
 
*[[Ankylosis]]
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==Etiopathology==
 
==Etiopathology==
 
The etiopathology is very different in individual patients. Mild forms of the disease can spontaneously decline after weeks. In other cases, the disease can assume intensity and eventually become so serious that normal lifestyles of patients are severely affected. Another form of etiopathology is the alternation between [[remission]] and [[exacerbation]].
 
The etiopathology is very different in individual patients. Mild forms of the disease can spontaneously decline after weeks. In other cases, the disease can assume intensity and eventually become so serious that normal lifestyles of patients are severely affected. Another form of etiopathology is the alternation between [[remission]] and [[exacerbation]].
 +
 
==Classification==
 
==Classification==
 
===Classification according to etiology===
 
===Classification according to etiology===
#CRPS Type I (Synonyms: RSD, Sudeck’s syndrome): CRPS, which occurs after trauma or immobilization of an extremity, but without any specific nerve damage
+
* CRPS Type I (Synonyms: RSD, Sudeck's syndrome): CRPS, which occurs after trauma or immobilization of an extremity, but without any specific nerve damage
#CRPS Type II (Synonym: Causalgia): CRPS, which occurs after a nerve injury, but not necessarily limited to the location of the injury.  
+
* CRPS Type II (Synonym: Causalgia): CRPS, which occurs after a nerve injury, but not necessarily limited to the location of the injury.  
  
==Classification according to degree of severity==
+
===Classification according to degree of severity===
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<dcMediaViewer title = "Sudeck's atrophy after ankle fracture" showtitle= "yes" align="right" size="s" items="img_13943" />
 
The classification in the degrees of severity is not always clearly demarcated, since the individual symptoms can overlap and the progression of the disease is interindividually very different.
 
The classification in the degrees of severity is not always clearly demarcated, since the individual symptoms can overlap and the progression of the disease is interindividually very different.
#Grade 1 (acute stage): Circumscribed pain at the location of the injury, hyperesthesia, soft edema, muscular cramps, restriction of movements and hyperhidrosis
+
* Grade 1 (acute stage): Circumscribed pain at the location of the injury, hyperesthesia, soft edema, muscular cramps, restriction of movements and hyperhidrosis
#Grade 2 (dystrophic stage): Increasingly nonspecific pain condition, indurated edema, growth disturbances of hair and nails, osteoporosis and incipient amyotrophia ·
+
* Grade 2 (dystrophic stage): Increasingly nonspecific pain condition, indurated edema, growth disturbances of hair and nails, osteoporosis and incipient amyotrophia
#Grade 3 (atrophic stage): Pain that can no longer be localized, irreversible tissue atrophy and generalization of the medical condition.  
+
* Grade 3 (atrophic stage): Pain that can no longer be localized, irreversible tissue atrophy and generalization of the medical condition.  
  
 
==Diagnosis==
 
==Diagnosis==
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*GLOA ([[ganglionic opioid analgesia]]).  
 
*GLOA ([[ganglionic opioid analgesia]]).  
  
Ganglionic opioid analgesia (GLOA) at the ganglion stellatum with Buprenorphine (Temgesic®) – not to be mistaken for the stellatum blockade – is one of the most effective therapy approaches so far with good chances of healing. Unfortunately, it is not widely used so far.  
+
Ganglionic opioid analgesia (GLOA) at the ganglion stellatum with Buprenorphine (Temgesic®) - not to be mistaken for the stellatum blockade - is one of the most effective therapy approaches so far with good chances of healing. Unfortunately, it is not widely used so far.  
  
 
===Other therapy===
 
===Other therapy===
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And many others.  
 
And many others.  
  
==Links==
+
==Literatur==
 +
* [http://litbot.doccheck.com/de/cont_40.startseite.php?page=1&abstractid=22669356 B. Zernikow et al: Please don't hurt me! - A plea against invasive procedures in children and adolescents with complex regional pain syndrome (CRPS), in Schmerz, 2012 Jun 6; Epub 2012 Jun 6]
 +
 
 +
==Weblinks==
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* [http://www.rsds.org RSDSA Website]
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[[de:CRPS]]
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[[Tag:Chronic]]
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[[Tag:Fracture]]
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[[Tag:Nerve]]
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[[Tag:Pain]]
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[[Tag:Trauma]]

Latest revision as of 12:24, 26 January 2018

CRPS stands for Complex Regional Pain Syndrome

Synonyms: reflex sympathetic dystrophy syndrome, Sudeck's syndrome, causalgia, shoulder-hand syndrome, a.o.

German: CRPS, Morbus Sudeck, Sudeck Krankheit, Sudeck'sche Dystrophie, Sudeck-Dystrophie, Algodystrophie, Sympathalgie, Komplexes regionales Schmerzsyndrom, Sympathische Reflexdystrophie (SRD), Reflex Sympathetic Dystrophy Syndrome (RSD)

1 Definition

The CRPS is a chronic neurologic disease, which occurs after soft tissue or nerve injury, often in association with the fracture of an extremity. The old term "Sudeck's syndrome" is still frequently used to describe CRPS of type 1 named after its discoverer Paul Sudeck (1866-1945), a Hamburg-based surgeon.

2 Pathogenesis

The pathogenesis of CRPS is not completely understood, but appears to be associated with a diruption of the healing process of injured tissue. The occurrence of CRPS is not dependent on the severity of the injury; the injury can even be so insignificant that the patient doesn't remember it. As a result of the injury, a misregulation of the sympathetic nervous system occurs, which hinders the normal healing process and instead stimulates a circulus vitiosus of pain and subsequent reaction of the sympathetic nervous system.

3 Epidemiology

CRPS occurs in about 1-2% of patients who have had fractures and in approximately 2-5% of patients after peripheral nerve injuries.

4 Symptoms

The CRPS symptoms are unspecific at the beginning and are often falsely interpreted and/or not seriously considered by the treating physician. CRPS is however a disease and not an indisposition. Typical symptoms of the disease are:

  • Burning pain
  • Edemas
  • Hyperhidrosis
  • Increased or decreased skin temperature
  • Hyperesthesia
  • Allodynia
  • Restriction of movement
  • Skin changes (livid complexion, dry skin, seborrheic skin)
  • Altered hair and nail growth

Advanced symptoms are:

5 Etiopathology

The etiopathology is very different in individual patients. Mild forms of the disease can spontaneously decline after weeks. In other cases, the disease can assume intensity and eventually become so serious that normal lifestyles of patients are severely affected. Another form of etiopathology is the alternation between remission and exacerbation.

6 Classification

6.1 Classification according to etiology

  • CRPS Type I (Synonyms: RSD, Sudeck's syndrome): CRPS, which occurs after trauma or immobilization of an extremity, but without any specific nerve damage
  • CRPS Type II (Synonym: Causalgia): CRPS, which occurs after a nerve injury, but not necessarily limited to the location of the injury.

6.2 Classification according to degree of severity

The classification in the degrees of severity is not always clearly demarcated, since the individual symptoms can overlap and the progression of the disease is interindividually very different.

  • Grade 1 (acute stage): Circumscribed pain at the location of the injury, hyperesthesia, soft edema, muscular cramps, restriction of movements and hyperhidrosis
  • Grade 2 (dystrophic stage): Increasingly nonspecific pain condition, indurated edema, growth disturbances of hair and nails, osteoporosis and incipient amyotrophia
  • Grade 3 (atrophic stage): Pain that can no longer be localized, irreversible tissue atrophy and generalization of the medical condition.

7 Diagnosis

There is no simple test procedure to ensure the diagnosis of CRPS. The diagnosis is determined mostly from the typical clinical picture. The additional procedures are:

  • Readings of the skin temperature (infrared-thermometer)
  • X-ray diagnosis (spotted decalcification)
  • Three-phase-sequence scintigraphy (technetium-99)

7.1 Differential diagnosis

  • Lymph drainage disturbances (surgery, tumor)
  • Venous occlusion (thrombus)

8 Therapy

The therapeutic procedure for CRPS is dependent on the severity of the disease pattern. The potential measures are much diversified, as there is no therapy approach available that delivers satisfactory results for it alone.

8.1 Systemic therapy

8.2 Local therapy

Ganglionic opioid analgesia (GLOA) at the ganglion stellatum with Buprenorphine (Temgesic®) - not to be mistaken for the stellatum blockade - is one of the most effective therapy approaches so far with good chances of healing. Unfortunately, it is not widely used so far.

8.3 Other therapy

  • Acupuncture
  • Autogenic training

And many others.

9 Literatur

10 Weblinks

This page was last edited on 26 January 2018, at 12:24.

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