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1,3-Bisphosphoglyceric acid

Revision as of 22:49, 23 September 2017 by Konstantin Weil (Talk | contribs)

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Synonyms: 1,3-Bisphosphoglycerate, bisphosphoglyceric acid
Abbreviation: 1,3BPG
German: 1,3-Bisphosphoglycerat

1 Definition

1,3-Bisphosphoglyceric acid is an organic molecule which occurs in living beings. The three carbon atom structure is a metabolic intermediate of glycolysis and its reverse pathway gluconeogenesis, but also of the calvin cycle in plant photosynthesis.

2 Glycolysis

During the second part (amortization phase) of the glycolytic degradation of glucose to pyruvic acid, glyceraldehyde 3-phosphate (GAP) is oxidized to 1,3-Bisphosphoglyceric acid (1,3BPG) by the glyceraldehyde 3-phosphate dehydrogenase enzyme (GAPDH).

This step involves the reduction of NAD+ to NADH/H+. Remarkable about this reaction is that free inorganic phosphate is transferred to the carboxyl group, which is rather uncommon in biochemistry.

GAPDH: GAP + NAD+ + Pi → 1,3BPG + NADH/H+

The resulting 1,3-Bisphosphoglyceric acid contains an energy-rich carboxylic acid-phosphoric acid anhydride bond.

In the next step, the phosphoglycerate kinase (PGK) enzyme transfers the phosphate group from 1,3BPG to one molecule of ADP utilizing the energy stored in this anhydride bond. The products are 3-Phosphoglyceric acid (3PG) and ATP.

PGK: 1,3BPG + ADP → 3PG + ATP

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