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Wolff-Chaikoff effect

German: Wolff-Chaikoff-Effekt

1 Definition

The Wolff-Chaikoff effect is a compensatory mechanism of the healthy thyroid gland that prevents the development of thyrotoxicosis in situations of iodine excess.

2 Mechanism

Elevated intracellular iodine concentrations block the uptake of iodine in the follicular cell and the synthesis of thyroid hormones by the thyroid peroxidase. This process is self-limiting, giving rise to an escape phenomenon after several days.

The Wolff-Chaikoff effect is to be distinguished from the Plummer effect, where the proteolysis of thyroglobulin and the release of preformed thyroid hormones are inhibited by high iodine concentrations.

3 References

This page was last edited on 25 July 2022, at 11:47.

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