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DCCC is an abbreviation for the Diabetes Control and Complications Trial. This study has conclusively proven that intensified insulin therapy improves long-term glycemic control as measured by HbA1c fraction, and reduces the risk of development and progression of microvascular complications; the major drawback being 2-3 fold increase in severe hypoglycemic episodes.


  • The Diabetes Control and Complications Trial Research Group (1993), The effect of intensive therapy of diabetes on the development and progression of long-term complications in insulindependent diabetes mellitus. N Engl J Med; 329: 977-986.
  • Yadav S, Parakh A. (2006), Insulin therapy. Indian Pediatr. Oct;43(10):863-72.

This page was last edited on 24 November 2006, at 12:59.

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