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Cerebral blood volume

Synonym: CBV
German: zerebrales Blutvolumen

1 Definition

Cerebral blood volume (or CBV) refers to the volume of blood that is present at a given moment within the neocranium in order to perfuse the brain and meninges.

2 Physiology

The neurocranium of a typical human adult contains approximately:

Of this total volume of blood about 15% is located within arteries, 40% in veins and 45% in nervous tissue and capillaries.

The CBV values for the two main components of the brain are:

  • for gray matter: ca. 3,5ml/100g
  • for white matter: ca. 1,75ml/100g

Closely related to CBV is the cerebral blood flow, or CBF. Both CBV and CBF are dependent upon several important parameters:

3 Pathology

A significant increase in the volume of blood within the neocranium (as a consequence of, e.g. intracranial hematoma or acute cerebral hemorrhage) violates the Monro-Kellie doctrine and can cause a life-threatening increase in intracranial pressure. This can lead to either tentorial herniation or tonsillar herniation. An ischemic stroke, on the other hand, results in a significant reduction in the CBV.

Specialties: Anatomy

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