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Aldehyde dehydrogenase

Synonym: ALDH
German: Aldehyddehydrogenase

1 Definition

Aldehyde dehydrogenase, consist of a group of enzymes that catalyze the oxidation of aldehydes.

2 Backround

There are many different forms of aldehyde dehydrogenase within the human body, these are characterized by having several significant differences in their amino acid sequences. They can be classified into three groups:

  • ALDH-1
  • ALDH-2
  • ALDH-3

Aldehyde dehydrogenases are mainly found in the liver, where it is either found in the cytosol (ALDH-1) or in the mitochondria (ALDH-2).

3 Biochemistry

The alcohol dehydrogenases (ADH) convert ethanol into toxic acetaldehyde (alkanal) as part of its metabolism. Acetaldehyde is poisonous to the liver because it can lead to cirrhosis. The aldehyde dehydrogenase transforms the toxic acetaldehyde into non-toxic acetate.

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