Arzt

Heidelberg, Deutschland

I am an internationally trained physician scientist with clinical and research experiences across Europe and the United States.

After graduating from bilingual German/English high school in 2012, I studied Medicine at Heidelberg University and soon developed an avid interest in immune mediated diseases. Supported by grants and fellowships from the German National Academic Foundation, the Boehringer-Ingelheim Fonds and by an independent research award from the NIH/NIAMS-funded Joint Biology Consortium, I trained in basic and translational immunology at Brigham and Women's Hospital/Harvard Medical School. In my core project, we pursue the idea that different subsets of neutrophils, innate immune cells, may exist. Unraveling the heterogeneity of neutrophils in health and disease may ultimately allow precise therapeutic manipulation of just a fraction of cells, thereby diminishing inflammation while maintaining defense against infections.

A molecule responsible for significant heterogeneity of neutrophils is CD177, a neutrophil-exclusive surface molecule that presents PR3, a self antigen central to ANCA vasculitis. We were able to show that binding CD177 with a monoclonal antibody unleashes a set of integrin-mediated signals that impair human neutrophil migration (Bai﹡, Grieshaber-Bouyer﹡ et al. Blood. 2017). In ongoing studies in the Nigrovic Lab (www.nigroviclab.org) and as part of the Immunological Genome Project Consortium (www.immgen.org), I spearhead the use of CyTOF, single-cell and bulk RNA-Seq, functional assays, fresh human biosamples, and publicly-available large datasets to dissect the in vitro and in vivo significance of neutrophil subpopulations and their relationship with granulopoiesis and inflammatory disease.

Graduate Education
10/2012 – 05/2019
Medicine (MD) – Heidelberg University Faculty of Medicine

08/2016 – 09/2017
Visiting Student – Harvard Medical School

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