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Thyrostimulin

Synonyms: TSH 2, Thyreostimulin, Heterodimer A2B5, Corticotroph-derived glycoprotein hormone (CGH)
German: Thyreostimulin

Thyrostimulin is a peptide-hormone that has been found in the anterior pituitary lobe. It was first described in the year 2002 by Nakabayashi et al..

While its function is still unknown it seems to have an effect at G-Protein coupled heptahelical TSH receptors that is similar to that of thyrotropin.

Expression of thyrostimulin's two subunits has been demonstrated in pituitary, retina, skin and testis.

References

  • Okada SL, Ellsworth JL, Durnam DM, Haugen HS, Holloway JL, Kelley ML, Lewis KE, Ren H, Sheppard PO, Storey HM, Waggie KS, Wolf AC, Yao LY, Webster PJ (2006). A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor. Mol Endocrinol. 2006 Feb;20(2):414-25. Epub 2005 Oct 6.
  • Breous E, Wenzel A, Loos U (2005). Promoter cloning and characterisation of the transcriptional regulation of the human thyrostimulin A2 subunit. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):169-80. Epub 2005 Dec 22.
  • Nakabayashi K, Matsumi H, Bhalla A, Bae J, Mosselman S, Hsu SY, Hsueh AJ (2002). Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor. J Clin Invest. 2002 Jun;109(11):1445-52.

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