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Rheumatoid arthritis

Synonym: chronic polyarthritis (CP)
Lay term: rheumatism
German: Rheumatoide Arthritis

1 Definition

Rheumatoid arthritis is a chronic inflammation system disease, which occurs in the interior skin (synovium), of a joint and causes a clinical picture of a polyarthritis. Optionally, other organs may be affected. The disease shows an episodal progression, progressive history, which can lead to joint destruction and severe disabilities up to invalidity.

2 ICD10 code

  • M05: seropositive rheumatoid arthritis
  • M06: Other chronic polyarthritis

3 Cause

The exact causes of rheumatoid arthritis are not clear for the most part. It is an autoimmune disease, in which particular internal tissues (eg cartilage) and connective tissue of the body are attacked by antibodies and phagocytes of the immune system. There is a genetic predisposition for the disease: Rheumatoid arthritis frequently occurs in families and is associated with certain MHCs - or - HLAs. The presence of the genetic variant HLA-DRB1 is the main decisive, predisposing feature.

Women are up to four times more likely to be affected than men, with a peak incidence between 30 and 40 years old.

4 Diagnosis

4.1 Laboratory

5 Diagnostic Criteria

The American College of Rheumatology has defined 7 criteria that confirm the diagnosis of "rheumatoid arthritis":

  1. Morning stiffness of at least 60 minutes
  2. Joint swelling or effusion in at least 3 joint areas
  3. Arthritis of the hand and / or finger joints
  4. Symmetrical infestation of the same joints on both sides of the body
  5. Presence of rheumatoid nodules
  6. Positive rheumatoid factor and / or ACPA in serum
  7. Distal strap osteoporosis or erosion seen in an X-ray

Rheumatoid arthritis occurs when a patient fulfills at least 4 of 7 criteria. The first 4 criteria must exist for a period of at least 4 - 6 weeks.

6 Therapy

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