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Pickardt Syndrome

(Redirected from Pickardt's Syndrome)

Synonyms: Pickardt-Fahlbusch Syndrome, Pickardt's Syndrome
German: Pickardt-Syndrom

1 Definition

The term Pickardt Syndrome refers to a rare form of tertiary Hypothyroidism that is caused by interruption of portal vessels connecting hypothalamus and pituitary.

2 Etiology

Occlusion of portal vessels may origin from tumors or thrombosis. The most common cause is pituitary adenomas with suprasellar extension. Blood flow may also be interrupted by inflammatory diseases.

A congenital form of Pickardt-Fahlbusch syndrome is referred to as Pituitary stalk interruption syndrome (PSIS).

3 Pathophysiology

Pickardt-Fahlbusch syndrome represents a form of set point disease: In the consequence of interrupted blood flow, an inadequately low amount of TRH reaches the anterior pituitary lobe and hence release of TSH is very low, leading to understimulation of the thyroid with consecutive hypothyroidism, in spite of functional thyrotropic feedback control.

4 Other consequences

Other endocrine dysfunctions associated with Pickardt's Syndrome are suprasellar malfunctions like secondary hypogonadism or hyperprolactinemia. Rarely, posterior pituitary failure including diabetes insipidus may ensue.

5 Reference

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