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Lock and key model

1 Definition

The lock and key model also called Fisher's theory is one of two models which describe the enzyme-substrate interaction. The lock and key model assumes that the active site of the enzyme and the substrate are equal shaped. It supposes that the substrate fits perfectly into the active site of the enzyme.

2 Characteristics

A substrate is bond to the active site of the Enzyme by weak non-covalent bonds:

see also: induced fit model

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