Medicipate! Conserve your knowledge 
Medicipate!
Conserve your knowledge
 
Write article
Please log in to edit this article.

Esmolol

Brand names: Brevibloc® and many more
German: Esmolol

1 Definition

Esmolol is short acting drug of the class II group of beta blockers and cardiac dysrhythmia medications. Esmolol is indicated for various cardiovascular diseases.

2 Indications

Due to the very short effect timing of Esmolol, it is most often used for diagnostic purposes or as a prophylactic agent against tachycardia (for example during a surgical procedure). Esmolol is also drug of choice for aortic dissection.

3 General Information

Esmolol is administered intravenously. In blood, 60% of the active substance is bound to plasma proteins. The metabolism occurs through esterases- hydrolases located within the plasma. The average biological half-life is around 9 minutes. This makes Esmolol the shortest active beta blocker. Subsequently the substance is mostly eliminated extrarenally (extrarenal fraction 0,99). However, an Esmolol main metabolite can accumulate when an impaired renal function is present. Thus the application duration should be limited to 4 hours, if a glomerular filtration rate (GFR) of 30-60 ml/min is apparent. The usage of Esmolol in case of a GFR lower than 30 ml/min is contraindicated.

4 Mechanism of action

Heart rate (chronotropy), line velocity (dromotropy), contractility of the myocardial tissue (inotropy) and also the excitability of the heart (bathmotropy) are reduced through the blocking of cardial adrenergic receptors. The effect of the neurotransmitters, noradrenaline and adrenaline, is modulated in such a way that a vasodilation is accompanied by the contextual decrease of blood pressure. Esmolol is a selective beta blocker that avoids causing bronchospasms by not inhibiting the pulmonary adrenergic receptors (Beta-2).

5 Unintended side-effects

Thanks to Esmolol’s short half-life there are only very limited and short termed side-effects, such as bradycardia.

6 Contraindications

To comment on this article, .

Click here for creating a new article in the DocCheck Flexikon.

Initial author:

0 rating(s) (0 ø)
Share

15 Views

You have any questions?
Language:
Follow DocCheck: