Chronic lymphocytic leukemia
1 Definition 
Chronic lymphocytic leukemia (CLL) is a leukemic-occuring, low-grade B-non-Hodgkin lymphoma, with a proliferation of immunoincompetent B-cells. It is the most frequent type of leukemia in the western world and mainly affects elderly persons (more than 65% of all patients are 60 years and older). The exact cause of CLL is uncertain.
2 Symptoms 
3 Staging and Prognosis 
In 1975, Rai, Sawitsky and colleagues have introduced a CLL staging system :
|Stage 0||lymphocytosis in the blood and marrow only (survival > 120 months)|
|Stage I||lymphocytosis and adenopathy (survival ~ 95 months)|
|Stage II||lymphocytosis, splenomegaly and/or hepatomegaly (survival ~ 72 months)|
|Stage III||lymphocytosis, anemia (hb < 10) (survival ~ 30 months)|
|Stage IV||lymphocytosis, thrombocytopenia (plt < 100,000) (survival < 30 months)|
4 Literature 
- Rai KR, Sawitsky A, Cronkite EP: Clinical staging of chronic lymphocytic leukemia. Blood 1975 Aug; 46(2): 219-34
To comment on this article, please login..