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ABC transporter

German: ABC-Transporter

1 Definition

ATP-binding cassette transporters (ABC transporters) are a large family of transmembrane proteins that have an ATP-binding cassette as a common property and serve as transport proteins.

2 Background

ABC transporters most commonly occur in secreting tissues like the liver or intestines. Most of them are exporters that move their substrates out of the cell in a primary active transport. They are very clinically relevant because their substrates can also consist of foreign substances or medicinal agents.

Most ABC transporters are dimers. Each monomer contains one transmembrane domain and one ATP-binding domain - also called nucleotide-binding domain. ABC transporters in the liver have a great significance because here they transport cholesterol and bile acid to the bile ducts.

3 Substance secretion

The substances transported by ABC transporters include:

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